The METABOLIC SYNDROME is a cluster of common pathogenic conditions, that includes glucose intolerance, insulin resistance (pre-diabetes), hypertension, abdominal obesity, and dyslipidemia. Although excessive dietary intake, i.e. “over nutrition” is a known contributor to the metabolic syndrome, the actual causative agents in food have not been determined.    However, there is common agreement that it is characterized by a harmful inflammation.

We have shown that dietary AGEs – without the involvement of nutrients – promote harmful inflammation and impair insulin action in animal models and in humans. These studies helped to distinguish “over-nutrition” from the effects of pro-inflammatory food AGEs, a factor not previously considered. These findings indicated that restriction of AGEs could be an effective and economical intervention against the metabolic syndrome and its consequences.

It is however critical to demonstrate that this intervention (the AGE-less Way Program), if carried out over a longer period, i.e. one year, could help arrest the progression of three major “epidemics” associated with the metabolic syndrome: diabetes, obesity, and vascular disease.

Elegibility:

1)   Non-smoking subjects of any gender and race 50 years old or above

2)   At least three of the following five characteristics of the metabolic syndrome:

a.) Waist circumference:

Men: > 102 cm

Women: > 88 cm

b.) Blood pressure: > 130/85 mm Hg (or use of anti-BP   medication)

c.) HDL-cholesterol:

Men: < 40 mg/dL

Women: < 50 mg/dL

d.) Triglycerides: > 150 mg/dL  (or use of medications for high triglycerides such as fibrates or nicotinic acid)

e.) Fasting blood sugar > 100 mg/dl (or use of metformin), but a HbA1c <6.5%

If you believe you qualify and live in the New York area, please call us at 212-241-2567 or send us a message to: AGEStudy@mssm.edu

You can also get more information about this study at:

http://clinicaltrials.gov/ct2/show/NCT01363141